And then, beyond the chronic inflammation, there may or may not be various allergic-type phenomena in the individual patient with this disease. And the universal constant that I’ve been observing with mast cell activation disease actually is chronic inflammation.Episode Intro … Mast Cell Activation Disorder (MCAD) … And of course, if you’re talking about the central nervous system being affected, it’s certainly possible there could be psychiatric issues. But a wide range of other psychiatric phenomena can be seen. And so, you go system by system, and you can come up with a wide range of symptoms that are a result of this general theme of inflammation and allergic-type phenomena and abnormal growth and development that you can see in all of these systems. And I’m very excited to discuss mast cell activation disorder and/or histamine intolerance and kind of pick into some of these specifics and where to draw the line between the two and how we can diagnose, how we can treat, and really delve into this gentleman’s brain, who has quite a bit of expertise in that area. And through all I learned in diagnosing her, I began to realize this might be a whole lot more common than anybody might’ve suspected previously. And can you define for us what mast cell activation disorder is? The term mast cell activation disorder, or MCAD, actually is the new, call it an umbrella term, the term for describing the whole realm of diseases of the mast cell. There’s the part of the iceberg you can fairly easily see above the waterline, a waterline of relatively easy clinical recognizability, if you will. Back around 2008 is when I started kind of serendipitously getting into this area, making the diagnosis in my first patient.Well, there are present in every vascularized tissue, but they dominantly site themselves at the environmental interfaces and also perivascular sites. So a lot of patients describe intermittent problems with shortness of breath, much less commonly wheezing.
So, Lawrence, thank you so much for being on the show. And the more I began looking for it in my other mysteriously ill patients, the more I began finding it. And then, there’s the much larger bulk of the iceberg below the waterline.
But it’s just to say that it is possible to see any or, unfortunately sometimes, even all systems in the body affected by the disease.
That doesn’t say, of course, that every system will be affected by the disease.
I know of course—and please correct me if I’m wrong or off on any of these, but we may be able to provide a few buckets here that we can organize these into neurological – irritability, depression, brain fog; dermatological – rash, flushing, hives, runny nose; rheumatological – joint pain; and then also maybe things like insomnia, fatigue, as being some of the more common symptoms but not only limited to those. Dr LA: Well, I think probably the most important point about what you’re trying to get at here is that there really is no system in the body which is immune, so to speak, to potentially being affected by this disease, not even the immune system.
And I hadn’t figured out a shorter way to describe it yet. So maybe a good transition there then would be to try to list—and I know this may be challenging—some of the most common symptoms.