She was recognized for her role in Boys the same year, and later established herself in Telugu cinema by acting in several Telugu films during 2003–2012.Genelia received her first Filmfare Award in 2006 for her performance in the Telugu romantic film, Bommarillu, which earned her critical acclaim.At the Chennai International Fashion Week (CIFW) in December 2009, she appeared as a showstopper for designer Ishita Singh's spring-summer indigenous collection of 2010, showcasing the best of Indian and Western dresses.She also holds a Limca world record of delivering four different super hit films in four different languages, Ready (Telugu), Satya in Love (Kannada), Santosh Subramaniam (Tamil), and Jaane Tu...Indian film critic Rajeev Masand commented, "The adorable little imp from Jaane Tu…Ya Jaane Na has turned into a nagging harridan in this film, and how you wish she'd immediately enroll for acting lessons." D'Souza had a major role in 2011, starring as the Muslim warrior princess Arackal Ayesha, in her debut Malayalam film Urumi. She has appeared in South Indian cinema and Bollywood films.
Ya Jaane Na, which was an economic success across India and overseas, grossing The movie received favorable reviews, and Sify noted in their review that, "The life of the film is definitely Genelia and she has shown the varied emotions from innocence, sadness, romance and anger in equal proportions without a hitch." In 2009, Genelia was cast in the Hindi film Life Partner, in which she was criticized for her performance.
Sify concluded about her acting in their review that, "The scene stealer is Genelia with her innocent looks and cute mannerisms.
She does not overact and we just fall in love with her character.
In 2008, she gave critically acclaimed performances in Santosh Subramaniam, a Tamil remake of Bommarillu, and the Bollywood movie Jaane Tu... Having acted in several commercially successful movies in Telugu and Tamil, Genelia has established herself as one of the leading actresses of the South Indian film industry.
In addition to mainstream acting, Genelia has hosted the television show Big Switch, and is the brand ambassador of Fanta, Virgin Mobile India, Fastrack, LG Mobiles, Garnier Light, Margo, and Perk in India.