He was interviewed in Michael Moore's political documentary about gun violence, Bowling for Columbine, discussing possible motivations for the 1999 Columbine massacre; he denied allegations that his music was a contributory factor.
Shooter Jennings' album "Countach (For Giorgio)" (a tribute to Giorgio Moroder) features Manson performing guest vocals on a cover of David Bowie's "Cat People (Putting Out Fire)". On September 30, 2017, Manson was injured by two large falling stage props while he performed on stage at the Hammerstein Ballroom in New York, breaking his fibula in two places, requiring a plate and ten screws to be inserted in the bone, as well as another screw in his ankle, which he had sprained during a show in Pittsburgh.
He was working towards a degree in journalism and gaining experience in the field by writing articles for a music magazine, 25th Parallel.
In his role as music interviewer, he soon met several of the musicians to whom his own band was later compared, including Groovie Mann from My Life with the Thrill Kill Kult and Trent Reznor of Nine Inch Nails. While with The Spooky Kids, Manson teamed with Jeordie White (also known as Twiggy Ramirez) and Stephen Gregory Bier Jr.
Antichrist Superstar (co-produced by Trent Reznor) was an even greater success. Manson first worked as a producer with the band Jack Off Jill.
He helped name the band and produced most of the band's early recordings, and also played guitar on the song "My Cat" and had the band open most of his South Florida shows.