The show was canceled by ABC on May 12, 2008, despite strong ratings and a grassroots campaign from the show's fanbase to keep the show alive.
In April 2007, she starred in a dramatic short film Once Upon a Time.
Her first notable film role came in 2004 with the dark drama Lightning Bug with Bret Harrison, Kevin Gage and Ashley Laurence.
Branching into other arenas than acting, Prepon also served as executive producer of the film.
Prepon starred as Donna Pinciotti on the Fox sitcom That '70s Show from 1998 to 2006.
Celebrity Couple That 70’s show star Laura Prepon and Greek Star Scott Michael Foster, who first met at the Blush one year Anniversary returned to Blush for the OTM afterfight party on Saturday night. She also appeared in the 2005 Oxygen original romantic comedy Romancing the Bride.She also was the original voice for Hayley Smith on the Fox animated sitcom American Dad! In 2009, Prepon appeared in the CBS sitcom How I Met Your Mother as Karen, one of the girlfriends of Ted Mosby (Josh Radnor), in the episode "Sorry, Bro".Laura Prepon was dating Christopher Masterson, who played the oldest brother, Francis, in Malcolm in the Middle.He is also the elder brother of Danny Masterson, Prepon’s That ‘70s Show co-star. She later dated former Greek star, Scott Michael Foster.