Second, it will enhance the understanding of retinal sites and mechanisms of action of injury.Third, it will provide a basis for determining the translatability of experimental data to humans. Cellular and Structural Imaging Techniques in Glaucoma Diagnosis and Treatment. Adaptive Optics Imaging to Study Retinal Degeneration and Response to Treatment.The two-year rodent cancer bioassay remains the definitive source of information employed for cancer risk assessment, and using such conventional approaches, the US Environmental Protection Agency (US EPA) is actively working to address the need for an updated and expanded document that serves as the agency’s approach for assessing cancer risk from exposure to PAH mixtures.However, the time and resources required to perform two-year rodent bioassays for the range of environmental PAH mixtures are significant and serve as a disincentive to the development of these kinds of data.
The second speaker will show the utility of AO techniques coupled to advanced imaging techniques to precisely deliver visual stimuli to individual photoreceptors, such that visual function and retinal structure can be studied with cellular resolution in normal and diseased retinas.Moreover, knowing the deposited dose also will facilitate the extrapolation from experimental animals (rat, mouse, rabbit, pig, and monkey) to humans of all ages. Flemming Cassee, National Institute for Public Health and the Environment (RIVM) of the Netherlands and University of Utrecht, Bilthoven, Netherlands.Most importantly, incorporating such dosimetric methodologies in the study design enables particle toxicologists to bring Particle Dosimetry Continuum to Assess the Dose Based on Concentrations. Defining the Dose of Particles in Toxicological Studies: Applications of Advances in Dosimetry Models in Risk Assessment.If you are already a member, you can sign in by clicking here.If you do not currently have a user account, and would like to create one/become a member, click here to begin the singup process.