The session will be of interest to basic scientists, clinicians, and researchers engaged in drug development and testing. Jacque Duncan, University of California San Francisco, San Francisco, CA.
Fate of Inhaled Particle-Gas Mixture in the Respiratory Tract.This will be followed by a panel discussion of the merits of these alternative approaches and what steps are needed to move toward validation.Testing of Polycyclic Aromatic Hydrocarbons at the National Toxicology Program. The Genetic Toxicity of Complex Mixtures of Polycyclic Aromatic Hydrocarbons: Evaluating the Dose-Additivity Assumption Using a Transgenic Mouse Model. Mechanism-Based Classification of PAH Mixtures to Predict Carcinogenic Potential.These newer noninvasive and experimental techniques are readily applicable to the study of drugs and toxicants that produce pathophysiological alterations similar to known retinal and neurodegenerative diseases, or that exacerbate such existing conditions.The objective of the session is to present state-of-the-art research approaches to clinical and experimental animal model imaging and their utility in toxicological research and to show how the obtained data can be utilized for translational research.